Filtered By:
Drug: Insulin
This page shows you your search results in order of date.
Order by Relevance | Date
Total 61986 results found since Jan 2013.
Adipocyte glucocorticoid receptor inhibits immune regulatory genes to maintain immune cell homeostasis in adipose tissue
Endocrinology. 2023 Sep 20:bqad143. doi: 10.1210/endocr/bqad143. Online ahead of print.ABSTRACTGlucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood. We performed in vivo studies using adipocyte sp...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Shripa Amatya Dylan Tietje-Mckinney Schaefer Mueller Maria G Petrillo Matthew D Woolard Sushma Bharrhan A Wayne Orr Christopher G Kevil John A Cidlowski Diana Cruz-Topete Source Type: research
Effects of < em > Aeriscardovia aeriphila < /em > on growth performance, antioxidant functions, immune responses, and gut microbiota in broiler chickens
In conclusion, oral administration of A. aeriphila could improve the growth performance, serum antioxidant capacity, immune modulation, and gut health of broilers. Our findings may provide important information for the application of A. aeriphila in poultry production.PMID:37735944 | DOI:10.1631/jzus.B2200621
Source: J Zhejiang Univ Sci ... - September 22, 2023 Category: Science Authors: Muhammad Zahid Farooq Xinkai Wang Xianghua Yan Source Type: research
Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis
J Orthop Surg Res. 2023 Sep 22;18(1):713. doi: 10.1186/s13018-023-04119-3.ABSTRACTOsteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce only symptomatic relief. Platelet-rich plasma (PRP) is a platelet concentrate derived from autologous whole blood with a high concentration of platelets, which can exert anti-inflammatory and regenerative effects by releasing multiple growth factors and cytok...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai Source Type: research
MG53 does not mark cardiovascular risk and all-cause mortality in subjects with type 2 diabetes: a prospective, observational study
Subjects with type 2 diabetes (T2D) are characterized by a high cardiovascular morbidity and mortality. MG53, a marker of peripheral insulin resistance, has been linked with impaired β-cell function and decreased β-cell survival, and its circulating levels are increased in T2D. Its relationship with the cardiovascular risk profile and mortality in T2D is currently unknown.
Source: Diabetes Research and Clinical Practice - September 22, 2023 Category: Endocrinology Authors: Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini Source Type: research
Potential involvement of the bone marrow in experimental Graves ’ disease and thyroid eye disease
ConclusionCollectively, these data indicate that the bone marrow is activated in experimental Graves’ disease and TED, which is prevented by linsitinib. Linsitinib-mediated immune-inhibition is mediated, at least in part, by arginase-1 up-regulation, consumption of arginine and thereby immune inhibition.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research
Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis in diabetic kidney disease progression
CONCLUSION: Deficient insulin regulation of ENT2 activity contributes to chronically high adenosine levels and glomerular alterations that underline diabetic kidney disease progression.PMID:37734469 | DOI:10.1016/j.bbadis.2023.166890
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Raibel Suarez Carolina Villarreal Yessica Nahuelp án Claudia Jara Carlos Oyarz ún Sebasti án Alarcón Montserrat M D íaz-Encarnación Elena Guill én-Gómez Claudia Quezada Rody San Mart ín Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
Temporal optimization of exercise to lower fasting glucose levels
This study examined the effect of exercise timing on evening and overnight glucose concentrations in individuals who were non-obese with normal fasting glucose levels (Non-Ob; n = 18) and individuals with obesity (OB) with impaired fasting glucose levels (OB+IFG) and without (n = 16 and n = 18, respectively). Subjects were studied on three occasions (no exercise (NOEX)), morning exercise (AMEX; 0700 h) and evening exercise (PMEX; 2000 h). The evening meal was provided (1800 h) and blood samples were taken from 1740 to 0700 h and morning endogenous glucose production (EGP) was measured. Glucose and insulin concentrations in...
Source: The Journal of Physiology - September 21, 2023 Category: Physiology Authors: Jill A Kanaley J W Porter N C Winn G Lastra A Chockalingam R J Pettit-Mee G F Petroski C Cobelli M Schiavon E J Parks Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
D-pinitol ameliorated H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans
In this study, we intended to explore the anti-aging mechanism of DP, utilizing computer modeling techniques. The results demonstrated that DP significantly delayed H2O2-induced cellular senescence. Model PC12 cells treated with DP exhibited increased cell viability, increased antioxidant enzyme activity (SOD, CAT), and reduced ROS and MDA levels. Furthermore, DP was discovered to have a positive effect on healthy longevity. In C. elegans, DP treatment enhanced lifespan, stress capacity, antioxidant capacity (T-SOD/CAT/GSH-Px/MDA/ROS), and altered aging-related indicators of lipofuscin accumulation, pharyngeal pump rate, m...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 21, 2023 Category: Biochemistry Authors: Miaosi Zhang Zhe Xu Liangyong Shao Jilite Wang Zouyan He Yumei Jiang Ye Zhang Hao Wang Source Type: research
Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice
J Lipid Res. 2023 Sep 19:100449. doi: 10.1016/j.jlr.2023.100449. Online ahead of print.ABSTRACTActivation of brown adipose tissue (BAT) contributes to energy dissipation and metabolic health. Although mineralocorticoid receptor (MR) antagonists have been demonstrated to improve metabolism under obesity, the underlying mechanisms remain incompletely understood. We aimed to evaluate the role of BAT MR in metabolic regulation. After 8 weeks of high fat diet (HFD) feeding, BAT MR knockout (BMRKO) mice manifested significantly increased body weight, fat mass, serum fasting glucose and impaired glucose homeostasis compared to li...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Chu-Mao Chen Xiao-Qian Meng Hong Zhu Ting Liu Yuan Liu Lu-Jun Zhou Guo-Dong Zhu Xiao-Bei Chen Xu-Guang Guo Sheng-Zhong Duan Source Type: research
How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future!
Digital health should become an organic part of primary care in the future
I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs
Growth Factor-Loaded Microparticles Enhance 3D Bioprinted Muscle
Researchers at the Terasaki Institute in Los Angeles have developed a new method to create 3D printed muscle constructs with enhanced muscle cell alignment and maturation. The technique involves creating microparticles loaded with insulin-like growth...
Source: Medgadget - September 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Rehab Surgery artificial muscle TerasakiInst Source Type: blogs
Are menstrual disorders in adolescent girls related to metabolic disorders?
CONCLUSIONS: Adolescent girls with menstrual disorders are insulin resistant, regardless of PCOS diagnosis. The severity of menstrual disorders may be related to the incidence of lipid disorders in adolescent girls.PMID:37728458 | DOI:10.5114/pedm.2023.125364
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: El żbieta Foryś Adrianna Baran Aleksandra Dziurdzia Ewelina Jarosz-W ójcik Pawe ł Matusik Aneta Gawlik Ryszard Tomaszewski Agnieszka Zachurzok Source Type: research
Macrophage-associated markers of metaflammation are linked to metabolic dysfunction in pediatric obesity
CONCLUSION: MAFLD and other metabolic disorders in pediatric patients with obesity are associated with an elevation of adipose tissue macrophage-related inflammation markers.PMID:37729736 | DOI:10.1016/j.cyto.2023.156372
Source: Cytokine - September 20, 2023 Category: Molecular Biology Authors: Julia Lischka Andrea Schanzer Charlotte de Gier Susanne Greber-Platzer Maximilian Zeyda Source Type: research
